Severely immunocompromised patients* may produce replication-competent virus beyond 20 days and require additional testing and consultation with infectious disease specialist to determine the appropriate duration of isolation and precautions.įor people who are asymptomatic (never develop symptoms):.Some people with severe illness (e.g., requiring hospitalization, intensive care, or ventilation support) may produce replication-competent virus beyond 10 days that may warrant extending the duration of isolation and precautions for up to 20 days after symptom onset.
A test-based strategy can be considered in consultation with infectious disease experts. However, replication-competent virus has not been reliably recovered and infectiousness is unlikely.įor most people with a current laboratory-confirmed SARS-CoV-2 infection, isolation and precautions can be discontinued 10 days after symptom onset and after resolution of fever for at least 24 hours, without the use of fever-reducing medications, and with improvement of other symptoms.įor people who are severely ill or severely immunocompromised : Patients who have recovered from COVID-19 can continue to have detectable SARS-CoV-2 RNA in upper respiratory specimens for up to 3 months after illness onset. For people who are infected but asymptomatic (never develop symptoms), isolation and precautions can be discontinued 10 days after the first positive test. For people who are severely ill (i.e., those requiring hospitalization, intensive care, or ventilation support) or severely immunocompromised, extending the duration of isolation and precautions up to 20 days after symptom onset and after resolution of fever and improvement of other symptoms may be warranted. 
For most children and adults with symptomatic SARS-CoV-2, the virus that causes COVID-19, infection, isolation, and precautions can be discontinued 10 days after symptom onset and after resolution of fever for at least 24 hours and improvement of other symptoms.
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